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Leptin treatment on mouse diabetic models - ob/ob mice and db/db mice: relevance to leptin treatment on human diabetic subjects. Successful breeding and backcrossing onto different backgrounds are essential to create knockout models ob/ob mice are sterile and. Of these models, the ob/ob mouse, db/db mouse, zucker fatty rat, and zdf rat represent some of the earliest animal models developed and remain among the. This article has presented a general approach for thinking about organizational functioning and a process for using a model to analyze organizational problems.
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